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Reliable process monitoring in sterile API manufacturing

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Standardised process instrumentation for Yaguang’s global 3-in-1 equipment portfolio

Active pharmaceutical ingredients (APIs) form the basis of modern medicines, yet their production is one of the most challenging manufacturing processes in the pharmaceutical industry. As a pioneer in integrated filtration, washing and drying systems, Zhejiang Yaguang relies on precise process monitoring to support quality, safety and regulatory compliance. Today, standardised instrumentation solutions from WIKA are an integral part of Yaguang’s 3-in-1 equipment portfolio, supporting the company’s international growth strategy.

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“In the past, long-term operation under high temperatures, high pressures and frequent temperature fluctuations could affect measurement stability. Today, we place great importance on long-term instrument reliability, which is why WIKA instruments have become a standard component of our 3-in-1 equipment.”

Chen Jingbo
General Manager
Zhejiang Yaguang Technology Co., Ltd.

Challenge

Sterile production under demanding process conditions

Sterile API production requires aseptic manufacturing environments, zero cross-contamination and reliable operation under challenging process conditions. Many applications involve organic solvents, making explosion protection an additional requirement. At the same time, manufacturers must maintain strict quality standards and comply with increasingly stringent regulatory requirements.

Why reliable process instrumentation matters

Temperature fluctuations, elevated pressures and long operating cycles place exceptional demands on process instrumentation. Long-term measurement stability is critical for maintaining consistent production conditions and product quality. Inaccurate measurements can affect yields and, in extreme cases, result in batch rejection. As pharmaceutical equipment suppliers expand internationally, global service capabilities and recognised certifications become equally important.

Solution

WIKA and Yaguang: A partnership focused on reliability

Yaguang’s collaboration with WIKA began with an industrial evaporation project. During the early stages of cooperation, WIKA specialists provided technical consultation, application expertise and customised instrument selection tailored to the challenging conditions of the pharmaceutical process. Following the successful validation on Yaguang’s 3-in-1 equipment, WIKA instrumentation was adopted as the standard configuration across the entire product platform.

Standardised instrumentation for pharmaceutical applications

Today, WIKA’s pressure, temperature and process instrumentation is integrated across Yaguang’s 3-in-1 equipment portfolio. The combination of application-specific solutions, reliable measurement performance, international certifications and global service capabilities helps support demanding pharmaceutical manufacturing environments and international customer projects.

Benefits

Creating value through long-term collaboration

Reliable process monitoring is a critical success factor in sterile API manufacturing. By standardising on WIKA instrumentation solutions, Yaguang combines stable measurement performance with global support capabilities and internationally recognised standards. The result is a solution that strengthens operational reliability today while supporting the company’s longterm international growth ambitions. Looking ahead, both companies intend to strengthen their collaboration in areas such as IIoT applications, process optimisation and advanced monitoring solutions.

“Our partnership with Yaguang demonstrates how reliable instrumentation, technical expertise and close collaboration can create lasting value. Together, we support pharmaceutical manufacturers with solutions designed to meet demanding quality, safety and compliance requirements worldwide.”

Clark Xu
Food & Pharma Sales Key Account Manager, WIKA China

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Our solutions

SA-11 hygienic 3-A/EHEDG pressure sensor

SA-11 hygienic 3-A/EHEDG pressure sensor

Crevice-free and CIP/SIP-resistant, for aseptic measuring points
IS-3 pressure sensor

IS-3 pressure sensor

For reliable pressure measurement in hazardous areas
TR10 resistance thermometer

TR10 resistance thermometer

Whose sensor can be replaced during operation, for temperature control across filtration, washing and drying

Related solutions, products and technologies

Pharmaceuticals and biotechnology

Pharmaceuticals and biotechnology
Your free buyer’s guide: Pressure measurement technology for the food and beverage industry

Your free buyer’s guide: Pressure measurement technology for the food and beverage industry
Service

Service

Interesting facts

Strict requirements for sterile API production

■ Aseptic production with zero cross-contamination
■ Explosion-protected operation in solvent based environments
■ Extreme temperature fluctuations and elevated process pressures
■ Long-term measurement stability for reliable operation
■ Global service support and international certifications for worldwide projects

Zhejiang Yaguang Technology Co., Ltd.

■ Founded in 1996
■ More than 1,200 employees worldwide
■ More than 300 R&D specialists
■ Developer of China’s first integrated filtration, washing and drying system for sterile API production
■ Global supplier of pharmaceutical process equipment

Learn more about our customer success stories

Visit the Yaguang Technology website

Visit the Yaguang Technology website
View success story (PDF)

View success story (PDF)
Read more success stories from WIKA customers.

Read more success stories from WIKA customers.

Contact

Do you want to improve reliability, compliance and process stability in pharmaceutical manufacturing? Contact WIKA to learn more: